Demineralized bone matrix (DBM) refers to the bony portion of bones that remain after the mineral components of bone—mainly hydroxyapatite—are removed. This process of demineralization leaves behind collagenous proteins and bone morphogenetic proteins (BMPs) that retain osteoinductive properties capable of stimulating new bone formation. DBM acts as a natural scaffold to promote bone regeneration and healing.

The manufacturing process of Demineralized Bone Matrix involves cleaning and demineralizing allogeneic bone tissues—typically from cadaver bones—to remove immunogenic cells and mineral components. The cleaned bone tissues are demineralized using acid extraction methods to dissolve the mineral hydroxyapatite. This leaves behind an acid-demineralized bone matrix scaffold material rich in osteoinductive BMPs and collagen. The demineralized bone can be freeze-dried and milled into porous particulate or putty forms for easier handling and application in orthopedic and dental procedures. The processing eliminates any possibility of disease transmission.

 Get More Insights on Demineralized Bone Matrix